PATHOLOGIST MOST IMPORTANT MCQS, SIKKIM PSC EXAM QUESTION PAPER 2021

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Q1 : Best method to access haemoglobin 

(a) gasometric method 

(b) Acid-hematin method 

(c) Copper-Sulphate method 

(d) Cyn-Meth-Hb method 

ANSWER Key: D

Q2 : Increase in Serum homocysteine levels seen in 

(a) Iron deficiency Anaemia (b) Megaloblastic Anaemia 

(c) Sideroblastic Anaemia (d) Acute Tubulav Necrosis 

ANSWER Key: B  

Q3 : Special Stain for fat 

(a) Reticulin (b) Congo Red 

(c) Sudan III (d) Masson's Trichrome

ANSWER Key: C 

Q4 : Increased incidence of Mesothelioma seen in person exposed to 

(a) Asbestos (b) Barium (c) Iron (d) Copper

ANSWER Key: A

Q5 :Increased incidence of Renal cell Carcinoma seen in

(a) Von-Hippel-Lindau Syndrome (b) Wilson's Disease 

(c) Proteus Syndrome (d) Lyell's Syndrome 

ANSWER Key: A 

Q6 : Parasite found in the biliary tract 

(a) Enterobius Vermicularis (b) Trichuris Trichiura 

(c) Opisthorchis Sinensis (d) Trichinella Spiralis

ANSWER Key: C

Q7 : Birbeck granules seen in

(a) Acute Myeloid Leukaemia (b) Non-Hodgkin's Lymphoma 

(c) Carcinoma (d) Langerhan's Cell Histiocytosis 

ANSWER Key: D 

Q8 : Condyloma Acuminata is caused by

(a) Human Papilloma Virus (b) Herpes Simplex Virus 

(c) Picorna Virus (d) HHV 8

ANSWER Key: A 

Q9 : Sarcoma Botyroides is a type of 

(a) Leiomyosarcoma (b) Rhabdomyosarcoma

(c) Angiosarcoma (d) gliosarcoma

ANSWER Key: B 

Q10 : Useful biomarker for Medullary Carcinoma of thyroid 

(a) Calcitonin (b) - fetoprotein 

(c) glypican - 3 (d) myosin

ANSWER Key: A 

Q11 : In pseudogout, crystals are made of 

(a) Monosodium Urate (b) Calcium pyrophosphate 

(c) Sodium Carbonate (d) Potassium Dihydrate 

ANSWER Key: B

Q12 : Negri bodies in brain are pathognomic of 

(a) Plague (b) Rabies (c) Rickettsiae (d) Polyoma 

ANSWER Key: B

Q13 : Loss of E-Cadherin seen in 

(a) Infiltrating duct Carcinoma of breast 

(b) Colloid Carcinoma of breast 

(c) Neuroendocrine Carcinoma 

(d) Lobular Carcinoma of breast 

ANSWER Key: D

Q14 : Mycosis fungoides is a type of 

(a) B-cell Lymphoma (b) NK cell Lymphoma 

(c) Null cell Lymphoma (d) T cell Lymphoma 

ANSWER Key: D

 Q15 : Virus associated with Adult T cell Leukaemia / Lymphoma 

(a) Herpes Simplex Virus (b) Picorna Virus 

(c) HTLV - 1 (d) EBV 

ANSWER Key: C 

Q16: Retinoblastoma Locus is present on 

(a) chromosome 12p12 (b) chromosome 13q14 

(c) chromosome 11q14 (d) chromosome 9p12 

ANSWER Key: B 

Q17 : Tumor marker for Endodermal Sinus Tumor of ovary 

(a) - Fetoprotein (b) des Carboxy Prothrombin 

(c) gliadin (d) Cyclin - D1

ANSWER Key: A

Q18 : Main Androgen derivative responsible for Benign Hyperplasia of Prostate 

(a) Methyl Testosterone (b) 19 ? Nortestosterone 

(c) Ethisterone (d) Dihydrotestosterone 

ANSWER Key: D 

Q19 : Fontana Masson Reaction detects which pigment 

(a) Melanin (b) Carbon 

(c) Lipofuschin (d) Hematoidin

ANSWER Key: A 

Q20 : JAK - 2 mutation is demonstrable in

(a) Essential thrombocythemia (b) Fatty Liver 

(c) thallassemia (d) Carcinoma Cervix

ANSWER Key: A 

Q21 : Decrease in Reticulocyte count seen in 

(a) thallassemia (b) Iron Deficiency Anaemia 

(c) Megaloblastic Anaemia (d) Aplastic Anaemia

ANSWER Key: D  

Q22 : Serum Indirect Bilirubin is increased in 

(a) Hemolytic Anaemia (b) Hepatitis 

(c) Hypersensitivity reaction (d) Carcinoma Stomach 

ANSWERKey: A  

Q23 : In pancreatitis, type of necrosis seen is 

(a) Coagulation Necrosis (b) Liquefactive Necrosis 

(c) Fat Necrosis (d) Fibrinoid Necrosis 

ANSWERKey: C

Q24 : Lacunar R-S cell seen in 

(a) Lymphocyte Rich Hodgkin's Lymphoma 

(b) Nodular Sclerosis (c) Lymphocyte depleted 

(d) Mixed Cellularity 

ANSWER Key: B 

Q25 : Type of calcification seen in Hypervitaminosis D 

(a) Metastatic Calcification (b) Dystrophic Calcification 

(c) Compound Calcification (d) Simple Calcification 

ANSWER Key: A

Q26 : Michaelis - guttman bodies are seen in 

(a) Malakolakia (b) Leukoplakia 

(c) Dyskeratosis (d) Metaplasia

ANSWER Key: A  

Q27 : Rodent ulcer is a clinical term for 

(a) Basal Cell Carcinoma (b) Squamous Cell Carcinoma 

(c) Adenoid Cystic Carcinoma (d) Adeno Carcinoma 

ANSWERKey: A 

Q28 : Nasopharyngeal Carcinoma is associated with 

(a) Herpes Simplex Virus (b) Ebstein-Barr Virus 

(c) Picorna Virus (d) Adenovirus

ANSWER Key: B 

Q29 : Cobblestone appearance of intestine seen in

 (a) Crohn's Disease (b) Ulcerative Colitis 

(c) Carcinoma Colon (d) H. Pylori Gastritis

ANSWER Key: A

  Q30 : Caissons disease is a form of 

(a) Fat embolism (b) Aminotic Fluid Embolism 

(c) Air/Gas Embolism (d) Foreign body Embolism

ANSWER Key: C

Q31. The most important clinical feature in the diagnosis of Stein-Leventhal syndrome: 

(a) oligomenorrhoea or secondary amenorrhoea 

(b) obesity 

(c) Hirsutism 

(d) Infertility 

ANS Key: D 

Q32 : Pick the right one: 

Definite diagnostic procedure to detect invasive carcinoma of cervix is

 (a) Vaginal Cytology 

(b) Wedge Biopsy

(c) Cone Biopsy 

(d) Colposcopy 

Key: C 

Q33: Pick up the correct one:

 The concentration of Alpha-foeto Protein in maternal serum during normal pregnancy at 12-16 wks is (a) 100 g/L (b) 150 g/L

(c) 200 g/L (d) 250 g/L 

Key: B

Q34 : Earliest Feature of Xeropthalmia is 

(a) Night Blindness (b) Conjunctival Xerosis 

(c) Bitot spots (d) Dry Eye 

ANS. Key: A 

Q35 : The recommended content of Iodine in salt at the consumer level is 

(a) 10 ppm (b) 15 ppm 

(c) 20 ppm (d) 30 ppm

ANS.  Key: B 

Q36 : Enzyme raised in obstructive Jaundice

 (a) ALT (b) AST

 (c) Alkaline Phosphatase

 (d) LDH 

ANS. Key: C

Q37 : Best method to diagnose typhoid in the first week 

(a) Blood culture (b) Widal Test 

(c) Urine culture (d) Stool culture

ANS. Key: A 

Q38 : COVID-19 does not spread through

 (a) Fomites (b) Direct Contact 

(c) Mosquito Bite (d) Coughing

ANS. Key: C

Q39 : Swine flu is caused by 

(a) H1 N1 

(b) H2 N2 

(c) H1 N2 

(d) H1 N5

ANSWER Key: A 

H1 N5 = BIRD FLU

HI N2 = Influenza A virus

H1 N1 = Swine flu

H2 N2 = "Asian flu"

Q40 : Blood group that contains no antibodies 

(a) Group A (b) Group B 

(c) Group C (d) Group AB

ANS. Key: D 

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